By N. Ghista Dhanjoo, Eddie Yin-kwee Ng
For the 1st time, this helpful booklet indicates how cardiac perfusion and pumping could be quantified and correlated. Self-contained and unified in presentation, the reasons within the compendium are certain adequate to seize the reader s interest and entire sufficient to supply the history fabric to discover extra into the topic. Mathematically rigorous and clinically orientated, the e-book is an enormous source for biomedical engineers, cardiologists, cardiac surgeons and clinicians. for college students, it really is an excellent textbook for senior-level classes in cardiovascular engineering.
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Extra info for Cardiac perfusion and pumping engineering
Microblood ﬂow distribution by tracer autoradiography with 3 H-desmethyl-imipramine in rabbit subendocardial and subepicardial layers (B, C). Note the dense capillary network with H-, Y-, T-, and hairpin-type interconnection. There is coexistence of systolic and diastolic preponderant ﬂow through capillary network (A). Marked global microheterogeneity (high ﬂow in one region, but low ﬂow in other region) of blood ﬂow is recognized in subendocardial layer, while local (point-topoint) heterogeneity is more remarkable in subepicardial layer (revised from Refs.
The distribution of regional ∆H to total LV wall elasticity seems fairly uniform as opposed to the pathologic LV, where it is not. For this example, the CVs of ∆H for the pathologic and relatively healthy heart are 61% and 24%, respectively. Probably, a slight variation of the elastic properties of the normal LV depends on the diﬀerences of wall thickness, which in turn depend on the amount of cytoskeletal proteins per myocardial cross section. In the pathologic state, a high extent of ∆H June 6, 2007 6:8 WSPC/SPI-B421 Cardiac Perfusion and Pumping Engineering ch02 30 F.
2. General Considerations To avoid misunderstanding, we ﬁrst deﬁne “inhomogeneity”. Typically, to describe the diﬀerences in LV wall structure or function, we use diﬀerent terminologies such as “non-uniformity”, “non-homogeneity”, “heterogeneity”, or “inhomogeneity”. Commonly, diﬀerent terms are used to describe the same phenomenon, and the same term is used to describe diﬀerent phenomena. Perhaps the main source of confusion lies in the anticipated causal relation between diﬀerences of LV structure and function.