By Srihari S. Naidu
This publication presents a accomplished medical overview of Hypertrophic Cardiomyopathy (HCM), the commonest genetic illness of the guts characterised by means of dysfunctional contractility on the sarcomere point, leading to the advance of irregular and sometimes focal hypertrophy on a macroscopic point.
Editor, Srihari S. Naidu, has introduced jointly a global popular staff of specialists to study a variety of diversified subject matters yet, with a realistic concentration that might permit readers to set up the evidence-based most sensible perform in any capability state of affairs. remedy modalities together with drugs, pacemakers and defibrillators, and invasive septal relief treatment (both surgical myectomy and alcohol septal ablation) could be mentioned. Chapters on genetics, relations screening, way of life issues, and athletic screening have also been extra given the continuing controversies and changes of opinion on lots of those concerns.
Each bankruptcy inside of Hypertrophic Cardiomyopathy starts off with key issues of information and ends with scientific pearls that experience no longer formerly been disseminated to the broader neighborhood. the sensible process of the full booklet maintains with devoted chapters on making a heart of Excellence, together with the right way to facilitate the multi-disciplinary technique, and on case-based stories and discussions permitting readers to additional know how to combine the data won from each one bankruptcy into the excellent and longitudinal care of the person sufferer and kinfolk. The final bankruptcy takes the reader in the course of the administration of tangible sufferers, exhibiting over a long time the nuances to prognosis and administration and the occasionally abrupt alterations during their illnesses that necessitate correspondingly abrupt variations in therapy.
This ebook might be an important textual content for Trainees, Fellows, citizens and board-certified physicians in cardiology, interventional cardiology, cardiac surgical procedure, cardiac imaging, activities drugs, paediatric cardiology, genetics and genetic counselling, and electrophysiology.
Read Online or Download Hypertrophic Cardiomyopathy: Foreword by Bernard Gersh and Historical Context by Eugene Braunwald PDF
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Additional info for Hypertrophic Cardiomyopathy: Foreword by Bernard Gersh and Historical Context by Eugene Braunwald
Summary With the passage of time and advances in knowledge, the historical misconceptions regarding HCM as a rare disease with poor prognosis have been dispelled to a large degree. Current understanding of this common disease suggests that the natural history is indeed benign for the HCM patient population as a whole, with annual sudden death mortality rates of <1 %. However, a subgroup of high-risk patients and those with obstructive physiology remain at risk for complications such as heart failure progression, advanced symptoms, atrial fibrillation, and stroke.
2009;30: 2599–605. 3 Pathology and Pathophysiology Kazuyuki Yahagi, Elena Ladich, and Renu Virmani Abstract Hypertrophic cardiomyopathy (HCM) is a primary and usually familial cardiac disorder with heterogeneous expression, unique pathophysiology, and a diverse clinical course. Clinically HCM requires a hypertrophied non-dilated left ventricle without evidence of any other cardiac or systemic disease that could produce the extent of hypertrophy observed. In the vast majority of individual adults dying from HCM, there is cardiomegaly typically in the range of twice the normal heart weight.
Eur Heart J. 2010;31:2111–23. 21 59. Ho CY, Carlsen C, Thune JJ, et al. Echocardiographic strain imaging to assess early and late consequences of sarcomere mutations in hypertrophic cardiomyopathy. Circ Cardiovasc Genet. 2009;2: 314–21. 60. Carasso S, Yang H, Woo A, et al. Systolic myocardial mechanics in hypertrophic cardiomyopathy: novel concepts and implications for clinical status. J Am Soc Echocardiogr. 2008;21:75–83. 61. Maron MS, Appelbaum E, Harrigan CJ, et al. Clinical profile and significance of delayed enhancement in hypertrophic cardiomyopathy.